Journalartikel

Jahr der Veröffentlichung: 1995

Seiten: 309-314

Zeitschrift: Naunyn-Schmiedeberg's Archives of Pharmacology

Bandnummer: 351

Heftnummer: 3

ISSN: 0028-1298

DOI Link: https://doi.org/10.1007/BF00233252

Verlag: Springer

Abstract: 
human cancer. One of the side-effects of irinotecan is a strong diarrhoea. In order to investigate the mechanism underlying this diarrhoea, the effect of irinotecan on anion secretion across the isolated rat distal colon was studied. Irinotecan caused a concentration-dependent increase in short-circuit current (Isc). The increase in Isc was completely dependent on the presence of Cl- ions and was supressed by furosemide and the Cl- channel blocker NPPB (5-nitro-2-(3-phenylpropylamino)-benzoate), indicating that it is caused by a Cl- secretion. The secretory response was inhibited by indomethacin, 1-benzylimidazole, a thromboxane synthase inhibitor, and SKandF 88046 ((N,N'-bis [7-(3-Chlorobenzeneaminosulfonyl)-1,2,3, rahydroisoquinolyl)disulfonylimide), a thromboxane A, receptor blocker. In isolated crypts irinotecan had no effect on the membrane potential. Consequently, the secretion induced by irinotecan is an indirect one, caused by the stimulation of eicosanoid production, e.g. thromboxane A(2), in the subepithelial tissue.

Harvard-Zitierstil: Sakai, H., Diener, M., Gartmann, V. and Takeguchi, N. (1995) Eicosanoid-mediated Cl− secretion induced by the antitumor drug, irinotecan (CPT-11), in the rat colon, Naunyn-Schmiedeberg's Archives of Pharmacology, 351(3), pp. 309-314. https://doi.org/10.1007/BF00233252

APA-Zitierstil: Sakai, H., Diener, M., Gartmann, V., & Takeguchi, N. (1995). Eicosanoid-mediated Cl− secretion induced by the antitumor drug, irinotecan (CPT-11), in the rat colon. Naunyn-Schmiedeberg's Archives of Pharmacology. 351(3), 309-314. https://doi.org/10.1007/BF00233252