Mechanisms and Regulation of C1- Secretion in the Large Intestine: Studies with the Rat Distal Colon - Research portal of Justus Liebig University Giessen:

Contribution in an anthology

Mechanisms and Regulation of C1- Secretion in the Large Intestine: Studies with the Rat Distal Colon

Authors list: Diener, M

Appeared in: Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Basic Science to Clinical Perspectives

Editor list: Gaginella, TS; Mózsik, G; Rainsford, KD

Publication year: 1997

Pages: 95-102

ISBN: 978-94-011-5390-4

DOI Link: https://doi.org/10.1007/978-94-011-5390-4_9

Abstract:

Chloride secretion is under the intracellular control of at least three intracellular second messenger pathways, the cAMP-, the Cа²⁺- and the cGMP-system. An increase in the intracellular cAMP concentration causes the opening of apical Cl^- channels and a stimulation of the basolateral Na⁺-K⁺-C1^--cotransporter responsible for intracellular C1^- accumulation. In contrast, the effect of intracellular Ca²⁺ is, at least in isolated crypts from the rat distal colon, restricted to the opening of a basolateral Са²⁺-dependent K⁺ conductance, which leads to a hyperpolarization of the membrane and thereby increases the driving force for Cl^- exit across spontaneously open apical Cl^- channels. In the rat distal colon, there is evidence for a modulation of cAMP-mediated secretion by intracellular cGMP, which affects Cl^- secretion indirectly via a cGMP-sensitive phosphodiesterase, an enzyme which is responsible for cAMP degradation. These studies suggest a complex interaction of all three signalling pathways in the intracellular regulation of Cl^- secretion.

Authors/Editors

- Uni.-Prof. Dr. Martin Heinz Diener

Citation Styles

Harvard Citation style: Diener, M. (1997) Mechanisms and Regulation of C1- Secretion in the Large Intestine: Studies with the Rat Distal Colon, in Gaginella, T., Mózsik, G. and Rainsford, K. (eds.) Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Basic Science to Clinical Perspectives. Dordrecht: Springer Netherlands, pp. 95-102. https://doi.org/10.1007/978-94-011-5390-4_9

APA Citation style: Diener, M. (1997). Mechanisms and Regulation of C1- Secretion in the Large Intestine: Studies with the Rat Distal Colon. In Gaginella, T., Mózsik, G., & Rainsford, K. (Eds.), Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Basic Science to Clinical Perspectives (pp. 95-102). Springer Netherlands. https://doi.org/10.1007/978-94-011-5390-4_9