Mechanisms of Chloride and Bicarbonate Secretion Across Rat Proximal Colon Evoked by a CO Donor - Research portal of Justus Liebig University Giessen:

Meeting Abstract

Mechanisms of Chloride and Bicarbonate Secretion Across Rat Proximal Colon Evoked by a CO Donor

Authors list: Steidle, Julia; Diener, Martin

Publication year: 2011

Journal: Zeitschrift für Gastroenterologie

Volume number: 49

DOI Link: https://doi.org/10.1055/s-0031-1304775

Conference: III. Kloster Arnsburg – Meeting Intestinale Mucosafunktion

Publisher: Georg Thieme Verlag

Abstract:

The aim of the present study was to investigate whether carbon monoxide induces changes in ion transport across rat proximal colon. In Ussing chamber experiments, tricarbonyldichlororuthenium(II) dimer (RuCO), a CO-donor, evoked a concentration-dependent increase in short-circuit current (I_sc). Anion substitution experiments suggest that a secretion of Cl⁻ and HCO₃ ⁻ underlie the RuCO-induced current. Partial inhibition by the neurotoxin tetrodotoxin suggests the involvement of secretomotor neurons in this response. Consequently, endogeneous carbon monoxide might be a physiological modulator of colonic ion transport.

Authors/Editors

- Uni.-Prof. Dr. Martin Heinz Diener

Citation Styles

Harvard Citation style: Steidle, J. and Diener, M. (2011) Mechanisms of Chloride and Bicarbonate Secretion Across Rat Proximal Colon Evoked by a CO Donor, Zeitschrift für Gastroenterologie, 49, Article A15. https://doi.org/10.1055/s-0031-1304775

APA Citation style: Steidle, J., & Diener, M. (2011). Mechanisms of Chloride and Bicarbonate Secretion Across Rat Proximal Colon Evoked by a CO Donor. Zeitschrift für Gastroenterologie. 49, Article A15. https://doi.org/10.1055/s-0031-1304775