Journalartikel

Jahr der Veröffentlichung: 2014

Seiten: 185-192

Zeitschrift: Colloids and Surfaces B: Biointerfaces

Bandnummer: 117

ISSN: 0927-7765

eISSN: 1873-4367

DOI Link: https://doi.org/10.1016/j.colsurfb.2014.02.022

Verlag: Elsevier

Abstract: 
Trimeric catecholates have been designed for the stable immobilization of effector molecules on metal surfaces. The design of these catecholates followed a biomimetic approach and was inspired by natural multivalent metal binders, such as mussel adhesion proteins (MAPs) and siderophores. Three catecholates have been conjugated to central scaffolds based on adamantyl or trisalkylmethyl core structures. The resulting triscatecholates have been immobilized on TiO2 and stainless steel. In a proof of concept study we have demonstrated the high stability of the resulting nanolayers at neutral and slightly acidic pH. Furthermore, polyethylene glycol (PEG) conjugates of our triscatecholates have been synthesized and were immobilized on TiO2 and stainless steel. The PEG coated surfaces showed excellent antifouling properties upon exposure to human blood and bacteria as demonstrated by fluorescence microscopy, ellipsometry and a bacterial assay with Staphylococcus epidermidis. In addition, our PEG-triscatecholates showed no cytotoxicity against bone-marrow stem cells on TiO2. (C) 2014 Elsevier B.V. All rights reserved.

Harvard-Zitierstil: Khalil, F., Franzmann, E., Ramcke, J., Dakischew, O., Lips, K., Reinhardt, A., et al. (2014) Biomimetic PEG-catecholates for stabile antifouling coatings on metal surfaces: Applications on TiO₂ and stainless steel, Colloids and Surfaces B: Biointerfaces, 117, pp. 185-192. https://doi.org/10.1016/j.colsurfb.2014.02.022

APA-Zitierstil: Khalil, F., Franzmann, E., Ramcke, J., Dakischew, O., Lips, K., Reinhardt, A., Heisig, P., & Maison, W. (2014). Biomimetic PEG-catecholates for stabile antifouling coatings on metal surfaces: Applications on TiO₂ and stainless steel. Colloids and Surfaces B: Biointerfaces. 117, 185-192. https://doi.org/10.1016/j.colsurfb.2014.02.022