Journalartikel

Jahr der Veröffentlichung: 2023

Seiten: 1193-1200

Zeitschrift: Neurological Sciences

Bandnummer: 44

Heftnummer: 4

DOI Link: https://doi.org/10.1007/s10072-022-06511-z

Verlag: Springer

Abstract: 

Purpose: Recent studies postulate a high prognostic value of the Alberta Stroke Programme Early CT Score (ASPECTS) applied on non-contrast whole-brain flat-detector CT (FDCT) after successful endovascular treatment (EVT). The aim of this study was the evaluation of long-term patient outcome after endovascular treatment using postinterventional FDCT.
Methods: Using a local database (Stroke Research Consortium in Northern Bavaria, STAMINA), 517 patients with successful endovascular treatment (modified Thrombolysis in Cerebral Infarction (mTICI) ≥ 2B) due to acute ischaemic stroke (AIS) and large vessel occlusion (LVO) of the anterior circulation were recruited retrospectively. In all cases, non-contrast FDCT after EVT was analysed with special focus at ASPECTS. These results were correlated with the functional outcome in long-term (modified Rankin Scale (mRS) shift from pre-stroke to 90 days after discharge).
Results: A significant difference in FDCT-ASPECTS compared to the subgroup of favourable vs. unfavourable outcome (Δ mRS) (median ASPECTS 10 (10-9) vs. median ASPECTS 9 (10-7); p = 0,001) could be demonstrated. Multivariable regression analysis revealed FDCT-ASPECTS (OR 0.234, 95% CI - 0.102-0.008, p = 0.022) along with the NHISS at admission (OR 0.169, 95% CI 0.003-0.018, p = 0.008) as independent factors for a favourable outcome. Cut-off point for a favourable outcome (Δ mRS) was identified at an ASPECTS ≥ 8 (sensitivity 90.6%, specificity 35%).
Conclusion: For patients with LVO and successful EVT, FDCT-ASPECTS was found to be highly reliable in predicting long-term outcome.

Harvard-Zitierstil: Knott, M., Hoelter, P., Hock, S., Mühlen, I., Gerner, S., Sprügel, M., et al. (2023) Can flat-detector CT after successful endovascular treatment predict long-term outcome in patients with large vessel occlusion? An Alberta Stroke Programme Early CT Score-based study, Neurological Sciences, 44(4), pp. 1193-1200. https://doi.org/10.1007/s10072-022-06511-z

APA-Zitierstil: Knott, M., Hoelter, P., Hock, S., Mühlen, I., Gerner, S., Sprügel, M., Huttner, H., Schwab, S., Engelhorn, T., & Doerfler, A. (2023). Can flat-detector CT after successful endovascular treatment predict long-term outcome in patients with large vessel occlusion? An Alberta Stroke Programme Early CT Score-based study. Neurological Sciences. 44(4), 1193-1200. https://doi.org/10.1007/s10072-022-06511-z