Conference paper

Publication year: 2007

Pages: 525-532

Journal: European Journal of Cell Biology

Volume number: 86

Issue number: 9

ISSN: 0171-9335

eISSN: 1618-1298

DOI Link: https://doi.org/10.1016/j.ejcb.2007.03.003

Conference: Tri-National Workshop on Cell Biology of Intracellular Transport Processes

Publisher: Elsevier

Abstract: 
Reggie-1/flotillin-2 and reggie-2/flotillin-1 are ubiquitously expressed, well-conserved proteins that are associated with membrane microdomains known as rafts. Studies from us and others have suggested a role in various cellular processes such as insulin signaling, T cell activation, membrane trafficking, phagocytosis, and epidermal growth factor receptor signaling. Recent findings also demonstrate that reggie-1 is associated with cell motility and transformation. However, the exact function of reggie proteins remains to be clarified. In this review, we will focus on some recent findings that have shed new light on the elusive molecular function of these highly interesting proteins. We will especially discuss the emerging role of reggie proteins in membrane receptor signaling and membrane trafficking, with emphasis on the regulation of the molecular function of reggies by post-translational modifications such as phosphorylation and lipid modifications. (c) 2007 Elsevier GmbH. All rights reserved.

Harvard Citation style: Babuke, T. and Tikkanen, R. (2007) Dissecting the molecular function of reggie/flotillin proteins, European Journal of Cell Biology, 86(9), pp. 525-532. https://doi.org/10.1016/j.ejcb.2007.03.003

APA Citation style: Babuke, T., & Tikkanen, R. (2007). Dissecting the molecular function of reggie/flotillin proteins. European Journal of Cell Biology. 86(9), 525-532. https://doi.org/10.1016/j.ejcb.2007.03.003