Journal article

Publication year: 2005

Pages: 3231-3238

Journal: FEBS Letters

Volume number: 579

Issue number: 15

ISSN: 0014-5793

eISSN: 1873-3468

DOI Link: https://doi.org/10.1016/j.febslet.2005.03.029

Publisher: Wiley

Abstract: 

Endocytosis is a versatile tool to regulate the intensity, localization, half-life and function of signaling complexes (signalosomes) that form in cells upon binding of growth factors, cytokines and morphogens to their cognate receptors. Endocytic adaptors are non-catalytic proteins that assemble effectors and structural components of the endocytic machinery around the trafficking cargo and serve as scaffolds for signalosomes, which in turn modify their location and activity by various post-translational modifications. We discuss how breakdowns in the function of endocytic adaptors might facilitate impairment of tissue homeostasis and consequent tumor development.

Harvard Citation style: Crosetto, N., Tikkanen, R. and Dikic, I. (2005) Oncogenic breakdowns in endocytic adaptor proteins, FEBS Letters, 579(15), pp. 3231-3238. https://doi.org/10.1016/j.febslet.2005.03.029

APA Citation style: Crosetto, N., Tikkanen, R., & Dikic, I. (2005). Oncogenic breakdowns in endocytic adaptor proteins. FEBS Letters. 579(15), 3231-3238. https://doi.org/10.1016/j.febslet.2005.03.029