Journalartikel

Jahr der Veröffentlichung: 2017

Seiten: 389-400

Zeitschrift: Development Genes and Evolution

Bandnummer: 227

Heftnummer: 6

ISSN: 0949-944X

DOI Link: https://doi.org/10.1007/s00427-017-0595-2

Verlag: Springer

Abstract: 
Zinc finger transcription factors of the Sp6-9 group are evolutionarily conserved in all metazoans and have important functions in, e.g., limb formation and heart development. The function of Sp6-9-related genes has been studied in a number of vertebrates and invertebrates, but data from chelicerates (spiders and allies) was lacking so far. We have isolated the ortholog of Sp6-9 from the common house spider Parasteatoda tepidariorum and the cellar spider Pholcus phalangioides. We show that the Sp6-9 gene in these spider species is expressed in the developing appendages thus suggesting a conserved role in limb formation. Indeed, RNAi with Sp6-9 in P. tepidariorum leads not only to strong limb defects, but also to the loss of body segments and head defects in more strongly affected animals. Together with a new expression domain in the early embryo, these data suggest that Sp6-9 has a dual role P. tepidariorum. The early role in head and body segment formation is not known from other arthropods, but the role in limb formation is evolutionarily highly conserved.

Harvard-Zitierstil: Konigsmann, T., Turetzek, N., Pechmann, M. and Prpic, N. (2017) Expression and function of the zinc finger transcription factor Sp6-9 in the spider Parasteatoda tepidariorum, Development Genes and Evolution, 227(6), pp. 389-400. https://doi.org/10.1007/s00427-017-0595-2

APA-Zitierstil: Konigsmann, T., Turetzek, N., Pechmann, M., & Prpic, N. (2017). Expression and function of the zinc finger transcription factor Sp6-9 in the spider Parasteatoda tepidariorum. Development Genes and Evolution. 227(6), 389-400. https://doi.org/10.1007/s00427-017-0595-2