Journal article

Publication year: 2011

Pages: S193-S202

Journal: Molecular Nutrition & Food Research

Volume number: 55

Issue number: S2

ISSN: 1613-4125

DOI Link: https://doi.org/10.1002/mnfr.201100040

Publisher: Wiley

Abstract: 
Scope: Metabolic stress induced by chronic high-fat (HF) diet feeding or genetically induced diabetes impairs carnitine status. Herein, we tested the hypothesis that regular endurance exercise (EE) improves the HF diet-induced impairment of carnitine status through stimulating the expression of hepatic genes involved in carnitine synthesis and uptake.
Methods and results: Eighteen male C57BL/6 mice were assigned to three groups: group S received a standard diet, group HF received a HF diet, and group HF+EE received an HF diet and was regularly exercised on a treadmill. After 10 wk, mice of the HF and the HF+EE groups were highly obese and insulin resistant compared with mice of the S group (p<0.05), but mice of the HF+EE group were less insulin resistant than those of the HF group (p<0.05). The HF group had lower carnitine concentrations and mRNA and protein levels of genes involved in carnitine synthesis and uptake in the liver than the S group (p<0.05), whereas these parameters did not differ between the S group and the HF+EE group.
Conclusion: These findings indicate that regular EE reverses an HF diet-induced impairment of hepatic carnitine content by stimulating hepatic carnitine synthesis and uptake.

Harvard Citation style: Ringseis, R., Mooren, F., Keller, J., Couturier, A., Wen, G., Hirche, F., et al. (2011) Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet, Molecular Nutrition & Food Research, 55(S2), pp. S193-S202. https://doi.org/10.1002/mnfr.201100040

APA Citation style: Ringseis, R., Mooren, F., Keller, J., Couturier, A., Wen, G., Hirche, F., Stangl, G., Eder, K., & Krüger, K. (2011). Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet. Molecular Nutrition & Food Research. 55(S2), S193-S202. https://doi.org/10.1002/mnfr.201100040