Journalartikel

Jahr der Veröffentlichung: 2003

Seiten: 2830-2837

Zeitschrift: The Journal of Nutrition

Bandnummer: 133

Heftnummer: 9

ISSN: 0022-3166

DOI Link: https://doi.org/10.1093/jn/133.9.2830

Verlag: Elsevier

Abstract: 
The aim of this study was to investigate the effect of dietary oxidized fats on the lipoprotein profile and the atherogenicity of LDL. Two experiments with male Sprague-Dawley rats were conducted. In Experiment 1, diets with either fresh fat or oxidized fat, prepared by heating at temperatures of 50, 105 or 190degreesC, containing either 25 or 250 mg alpha-tocopherol equivalents/kg were used. In Experiment 2, diets with fresh or oxidized fat, heated at a temperature of 55degreesC, containing 25 mg alpha-tocopherol equivalents/kg; were used. In Experiment 1, rats fed all types of oxidized fats had higher concentrations of HDL cholesterol and lower ratios between plasma and HDL cholesterol than rats-fed the diet containing the fresh fat. As determined from the lag time, the susceptibility of LDL to copper-induced lipid peroxidation was higher in rats fed oxidized fats heated at 105 or 190degreesC than in rats fed the diets containing the fresh fat or the oxidized fat treated at 50degreesC, irrespective of the dietary vitamin E concentration. However, in Experiment 2, the composition of LDL apolipoproteins and uptake of LDL by macrophages were not different between rats fed the fresh fat diet and those fed the oxidized fat diet. We conclude that ingestion of oxidized fats does not adversely affect the lipoprotein profile in the rat model used, and does not cause modifications of apolipoproteins that would lead to enhanced uptake of LDL via macrophage scavenger receptors.

Harvard-Zitierstil: Eder, K., Keller, U., Hirche, F. and Brandsch, C. (2003) Thermally oxidized dietary fats increase the susceptibility of rat LDL to lipid peroxidation but not their uptake by macrophages, The Journal of Nutrition, 133(9), pp. 2830-2837. https://doi.org/10.1093/jn/133.9.2830

APA-Zitierstil: Eder, K., Keller, U., Hirche, F., & Brandsch, C. (2003). Thermally oxidized dietary fats increase the susceptibility of rat LDL to lipid peroxidation but not their uptake by macrophages. The Journal of Nutrition. 133(9), 2830-2837. https://doi.org/10.1093/jn/133.9.2830