Journal article

Publication year: 1995

Pages: 269-273

Journal: Journal of Animal Physiology and Animal Nutrition

Volume number: 74

Issue number: 4-5

ISSN: 0931-2439

DOI Link: https://doi.org/10.1111/j.1439-0396.1995.tb00460.x

Publisher: Wiley

Abstract: 
The effect of iron deficiency an parameters of thyroid hormone metabolism was examined in two experiments with 24 male weanling Sprague-Dawley rats. The animals were led a semisynthetic diet based on casein, containing either 9 mg Fe/kg (iron-deficient diet) or 60 mg Fe/kg (control diet). In experiment 1, all animals had free access to food. As food consumption in the iron-deficient animals was significantly decreased in contrast to controls, pair-feeding was introduced in experiment 2 to guarantee equal levels of consumption. Experiments 1 and 2 lasted for 40 days. In both experiments, iron-deficient rats had a lower live body weight at the end of the trial, and had an impaired feed-efficiency ratio. Concentrations of haemoglobin and haematocrit, erythrocyte count, and MCV were lowered by iron deficiency. Iron-deficient rats had lower concentrations of T-3 (experiment 1, - 42%; experiment 2, - 16%), T-4, (experiment 1, - 38%; experiment 2, - 78%), and fT(4) (experiment 1, - 15%; experiment 2, - 67%) than ad libitum- and pair-fed control rats. Iron deficiency impaired the activity of hepatic deiodinase. In the second experiment, this enzyme's activity was lowered by 75% in iron-deficient rats. and in che first experiment, the activin was even below the detection limit in iron-deficient rats. The results of this investigation demonstrate that iron might play a role in thyroid-hormone metabolism, especially via hepatic deiodinase activity.

Harvard Citation style: Kirchgeßner, M., Kralik, A. and Eder, K. (1995) Influence of alimentary iron deficiency on parameters of thyroid hormone metabolism in rats, Journal of Animal Physiology and Animal Nutrition, 74(4-5), pp. 269-273. https://doi.org/10.1111/j.1439-0396.1995.tb00460.x

APA Citation style: Kirchgeßner, M., Kralik, A., & Eder, K. (1995). Influence of alimentary iron deficiency on parameters of thyroid hormone metabolism in rats. Journal of Animal Physiology and Animal Nutrition. 74(4-5), 269-273. https://doi.org/10.1111/j.1439-0396.1995.tb00460.x