Journal article

Publication year: 2009

Pages: 4753-4762

Journal: Organic & Biomolecular Chemistry

Volume number: 7

Issue number: 22

ISSN: 1477-0520

eISSN: 1477-0539

DOI Link: https://doi.org/10.1039/b907831b

Publisher: Royal Society of Chemistry

Abstract: 
Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the benefit of therapy. Compounds able to modulate the intracellular redox state of cells have been developed, which effectively, yet also selectively, appear to kill cancer cells and a range of pathogenic microorganisms. Among the various agents employed, certain redox catalysts have shown considerable promise since they are non-toxic on their own yet develop an effective, often selective cytotoxicity in the presence of the 'correct' intracellular redox partners. Aminoalkylation, amide coupling and multicomponent reactions are suitable synthetic methods to generate a vast number of such multifunctional catalysts, which are chemically diverse and, depending on their structure, exhibit various interesting biological activities.

Harvard Citation style: Mecklenburg, S., Shaaban, S., Ba, L., Burkholz, T., Schneider, T., Diesel, B., et al. (2009) Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents, Organic and Biomolecular Chemistry, 7(22), pp. 4753-4762. https://doi.org/10.1039/b907831b

APA Citation style: Mecklenburg, S., Shaaban, S., Ba, L., Burkholz, T., Schneider, T., Diesel, B., Kiemer, A., Röseler, A., Becker, K., Reichrath, J., Stark, A., Tilgen, W., Abbas, M., Wessjohann, L., Sasse, F., & Jacob, C. (2009). Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents. Organic and Biomolecular Chemistry. 7(22), 4753-4762. https://doi.org/10.1039/b907831b