Journal article

Publication year: 1999

Pages: 271-281

Journal: Journal of Animal Physiology and Animal Nutrition

Volume number: 82

Issue number: 5

ISSN: 0931-2439

DOI Link: https://doi.org/10.1046/j.1439-0396.1999.00243.x

Publisher: Wiley

Abstract: 
This study was carried out ro investigate the effects of a dietary oxidized oil on several metabolic parameters in miniature pigs fed on a hyperlipidaemic diet. Therefore, an experiment with miniature pigs was conducted in which the animals were allotted to two groups and received a diet containing 20% of either fresh or thermoxidized oil with high levels of saturated fatty acids and 0.15% of cholesterol. Fatty acids and vitamin E concentrations of Loth fats were equalized by using different fat mixtures and individually supplementation of fats with DL-alpha-tocopherol acetate. The feeding period was 30 days. The amounts of diets administered were calculated to give an energetic levels of 50% above the requirement for maintenance. The body weight grins of the pigs during the experimental periods were similar for control and oxidized oils. However, feeding the oxidized oil markedly reduced the concentrations of cholesterol in plasma as lipids to lipid peroxidation by incubation with copper plasma as well as in low-(LDL) and high-density-lipoprotein (HDL) fractions. The susceptibility of plasma lipids to lipid peroxidation by incubation with copper ions was not significantly altered by feeding the oxidized oil although the concentration of sr-tocopherol in plasma was markedly reduced. The osmotic fragility of erythrocytes as well as the fatty acid composition of erythrocyte membrane total lipids was similar in pigs fed fresh and those fed the oxidized oil. However, feeding the oxidized oil reduced the concentration of triiodothyronine in plasma, and thus elevated the ratio between thyroxine and triiodothyronine. The study therefore shows that dietary oxidized oils influence the cholesterol and thyroid hormone metabolism and reduce the vitamin E status at identical fatty acid and vitamin E intake compared with control animals fed diets with fresh oils.

Harvard Citation style: Eder, K. (1999) The effect of an oxidized dietary oil on plasma cholesterol and thyroid hormone concentrations in miniature pigs fed on a hyperlipidaemic diet, Journal of Animal Physiology and Animal Nutrition, 82(5), pp. 271-281. https://doi.org/10.1046/j.1439-0396.1999.00243.x

APA Citation style: Eder, K. (1999). The effect of an oxidized dietary oil on plasma cholesterol and thyroid hormone concentrations in miniature pigs fed on a hyperlipidaemic diet. Journal of Animal Physiology and Animal Nutrition. 82(5), 271-281. https://doi.org/10.1046/j.1439-0396.1999.00243.x