Journal article

Publication year: 2003

Pages: 121-129

Journal: European Journal of Lipid Science and Technology

Volume number: 105

Issue number: 3-4

ISSN: 1438-7697

DOI Link: https://doi.org/10.1002/ejlt.200390027

Publisher: Wiley

Abstract: 
Two experiments with rats were carried out to investigate the effect of dietary fish oil and oxidized cholesterol on the concentration of 7beta-hydroxycholesterol, an oxysterol of mainly nonenzymatic origin, in liver, plasma, low density lipoproteins and erythrocytes of rats at different vitamin E supply. In Experiment 1, four groups of rats received diets with coconut oil or salmon oil (100 g/kg diet) and vitamin E concentrations of 40 or 240 mg alpha-tocopherol equivalents/kg. In Experiment 2, eight groups of rats received diets supplemented with pure or oxidized cholesterol (5 g/kg), coconut oil or salmon oil (100 g/kg diet) and vitamin E concentrations of 40 or 240 mg alpha-tocopherol equivalents/kg. Rats fed the salmon oil diets had significantly higher concentrations of 7beta-hydroxycholesterol in liver, plasma, low density lipoproteins and erythrocytes than rats fed coconut oil diets. Rats fed the diets supplemented with oxidized cholesterol had significantly higher concentrations of 7beta-hydroxycholesterol in all the samples analyzed than rats fed pure cholesterol. Increasing the dietary vitamin E concentration from 40 to 240 mg alpha-tocopherol equivalents/kg diet reduced the concentration of 7beta-hydroxycholesterol in plasma; the concentrations of 7beta-hydroxycholesterol in liver, low density lipoproteins and erythrocytes were not influenced by the dietary vitamin E concentration. The study suggests that diets with fish oil or oxidized cholesterol are critical with respect to the formation of 7beta-hydroxycholesterol.

Harvard Citation style: Ringseis, R. and Eder, K. (2003) Effects of dietary fish oil and oxidized cholesterol on the concentration of 7 beta-hydroxycholesterol in liver, plasma, low density lipoproteins and erythrocytes of rats at various vitamin E supply, European Journal of Lipid Science and Technology, 105(3-4), pp. 121-129. https://doi.org/10.1002/ejlt.200390027

APA Citation style: Ringseis, R., & Eder, K. (2003). Effects of dietary fish oil and oxidized cholesterol on the concentration of 7 beta-hydroxycholesterol in liver, plasma, low density lipoproteins and erythrocytes of rats at various vitamin E supply. European Journal of Lipid Science and Technology. 105(3-4), 121-129. https://doi.org/10.1002/ejlt.200390027