Journalartikel

Jahr der Veröffentlichung: 2005

Seiten: 3-9

Zeitschrift: International Journal for Vitamin and Nutrition Research

Bandnummer: 75

Heftnummer: 1

ISSN: 0300-9831

DOI Link: https://doi.org/10.1024/0300-9831.75.1.3

Verlag: Hogrefe

Abstract: 
This study was undertaken to investigate the bioavailability of various L. carnitine esters (acetyl-L-carnitine and lauroyl-L-carnitine) and salts (L-carnitine L-tartrate, L-carnitine fumarate, L-carnitine magnesium citrate) relative to base of free L-carnitine. Six groups of five or six piglets each were administered orally a single dose of 40 mg L-carnitine equivalents/kg body weight of each of those L-carnitine componds. A seventh-group served as a control. Free and total plasma carnitine concentration were determined 1, 2, 3.5, 7, 24, and 32 hours after adminstration of the single dose. Area under-the-curve (AUC) values were calulated to assess the bioavailability of the L-carnitine compounds. AUC values, calculated for the time interval between 0 and 32 hours, for both-free and total carnitine were similar for base of free L-carnitine and the three L-carnitine salts (L-carnitine L-tartrate, L-carnitine fumarate, L-carnitine magnesium citrate) while those of the two esters (acetyl-L-carnitine, lauroyl L-carnitine) were lower. Administration of L-carnitine L-tartrate yielded a higher plasma tree carnitine. AUC value for the time interval between 0 and 3.5 hours than administration of the other compounds. The data of this study suggest that L-carnitine salts have a similar bioavailability to that of free L-carnitine while L-carnitine esters have a lower one. The study also suggest that L-carnitine L-tartrate is absorbed faster than the other L-carnitine compounds.

Harvard-Zitierstil: Eder, K., Felgner, J., Becker, K. and Kluge, H. (2005) Free and total carnitine concentrations in pig plasma after oral ingestion of various L-carnitine compounds, International Journal for Vitamin and Nutrition Research, 75(1), pp. 3-9. https://doi.org/10.1024/0300-9831.75.1.3

APA-Zitierstil: Eder, K., Felgner, J., Becker, K., & Kluge, H. (2005). Free and total carnitine concentrations in pig plasma after oral ingestion of various L-carnitine compounds. International Journal for Vitamin and Nutrition Research. 75(1), 3-9. https://doi.org/10.1024/0300-9831.75.1.3