Journal article

Publication year: 2006

Pages: 704-708

Journal: Biochemical and Biophysical Research Communications

Volume number: 350

Issue number: 3

ISSN: 0006-291X

DOI Link: https://doi.org/10.1016/j.bbrc.2006.09.099

Publisher: Elsevier

Abstract: 
It has been shown that clofibrate treatment increases the carnitine concentration in the liver of rats. However, the molecular mechanism is still unknown. In this study, we observed for the first time that treatment of rats with the peroxisome proliferator activated receptor (PPAR)-alpha agonist clofibrate increases hepatic mRNA concentrations of organic cation transporters (OCTNs)-1 and -2 which act as transporters of carnitine into the cell. In rat hepatoma (Fao) cells, treatment with WY-14,643 also increased the mRNA concentration of OCTN-2. mRNA concentrations of enzymes involved in carnitine biosynthesis were not altered by treatment with the PPARalpha agonists in livers of rats and in Fao cells. We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis.

Harvard Citation style: Luci, S., Geissler, S., König, B., Koch, A., Stangl, G., Hirche, F., et al. (2006) PPARα agonists up-regulate organic cation transporters in rat liver cells, Biochemical and Biophysical Research Communications, 350(3), pp. 704-708. https://doi.org/10.1016/j.bbrc.2006.09.099

APA Citation style: Luci, S., Geissler, S., König, B., Koch, A., Stangl, G., Hirche, F., & Eder, K. (2006). PPARα agonists up-regulate organic cation transporters in rat liver cells. Biochemical and Biophysical Research Communications. 350(3), 704-708. https://doi.org/10.1016/j.bbrc.2006.09.099