Conference paper

Appeared in: Flavins and flavoproteins 1990

Editor list: Curti, B; Ronchi, S; Zanetti, G

Publication year: 1990

Pages: 851-854

ISBN: 0-89925-666-X

eISBN: 978-3-11-085542-5

DOI Link: https://doi.org/10.1515/9783110855425-165

Conference: 10th International Symposium on Flavins and Flavoproteins

Abstract: 

Human erythrocyte glutathione reductase (GR) is a homodimeric flavoenzyme of 105 kDa (1, 2). In vivo GR is not fully saturated with its prosthetic group FAD but the inactive apoenzyme can be completed in vitro according to the equation: apoGR + FAD —holoGR. This is the hypothetical basis for the determination of the erythrocyte glutathione reductase activation coefficient (EGRAC) which is defined as the ratio of FAD-stimulated to unstimulated activity of erythrocytic glutathione reductase (3). The activation coefficient is a reliable index for riboflavin deficiency in man (1). The multifacetted medical aspects, including interference with embryonic development and impaired protection from noxious chemicals, of this widespread hypovitaminosis have been reviewed comprehensively (1,4).

Harvard Citation style: Becker, K. and Schirmer, R. (1990) The EGRAC as a measure of the riboflavin status in man. Titration of hemolysate FAD with apoglutathione reductase, in Curti, B., Ronchi, S. and Zanetti, G. (eds.) Flavins and flavoproteins 1990. Berlin: de Gruyter. pp. 851-854. https://doi.org/10.1515/9783110855425-165

APA Citation style: Becker, K., & Schirmer, R. (1990). The EGRAC as a measure of the riboflavin status in man. Titration of hemolysate FAD with apoglutathione reductase. In Curti, B., Ronchi, S., & Zanetti, G. (Eds.), Flavins and flavoproteins 1990. (pp. 851-854). de Gruyter. https://doi.org/10.1515/9783110855425-165