Journalartikel

Jahr der Veröffentlichung: 2003

Seiten: 272-275

Zeitschrift: Redox Report: Communications in Free Radical Research

Bandnummer: 8

Heftnummer: 5

ISSN: 1351-0002

eISSN: 1743-2928

DOI Link: https://doi.org/10.1179/135100003225002899

Verlag: Taylor and Francis Group

Abstract: 
Methylene blue has intrinsic antimalarial activity and it can act as a chloroquine sensitizer. In addition, methylene blue must be considered for preventing methemoglobinemia, a serious complication of malarial anemia. As an antiparasitic agent, methylene blue is pleiotropic: it interferes with hemoglobin and heme metabolism in digestive organelles, and it is a selective inhibitor of Plasmodium falciparum glutathione reductase. The latter effect results in glutathione depletion which sensitizes the parasite for chloroquine action. At the Centre de Recherche en Sante de Nouna in Burkina Faso, we study the combination of chloroquine with methylene blue (BlueCQ) as a possible medication for malaria in endemic regions. A pilot study with glucose-6-phosphate dehydrogenase-sufficient adult patients has been conducted recently.

Harvard-Zitierstil: Schirmer, R., Coulibaly, B., Stich, A., Scheiwein, M., Merkle, H., Eubel, J., et al. (2003) Methylene blue as an antimalarial agent, Redox Report: Communications in Free Radical Research, 8(5), pp. 272-275. https://doi.org/10.1179/135100003225002899

APA-Zitierstil: Schirmer, R., Coulibaly, B., Stich, A., Scheiwein, M., Merkle, H., Eubel, J., Becker, K., Becher, H., Müller, O., Zich, T., Schiek, W., & Kouyate, B. (2003). Methylene blue as an antimalarial agent. Redox Report: Communications in Free Radical Research. 8(5), 272-275. https://doi.org/10.1179/135100003225002899