Journal article

Publication year: 1996

Pages: 288-291

Journal: Zeitschrift für Ernährungswissenschaft

Volume number: 35

Issue number: 3

ISSN: 0044-264X

DOI Link: https://doi.org/10.1007/BF01625694

Publisher: Springer Verlag (Germany)

Abstract: 
The aim of the present study was to investigate the effect of copper deficiency on thyroid hormone metabolism in rats. Therefore, an experiment with growing male Sprague-Dawley rats was carried out, consisting of two groups of rats fed either a copper-deficient (0.06 mg Cu/kg) or a copper-adequate diet (16 mg Cu/kg). Both groups of rats were fed identical quantities of diet by pair-feeding. Copper deficiency decreased the final body weight of the rats by 5 % compared to copper-adequate control rats. A severe copper-deficient state in the rats fed the copper-deficient diet was proved by a large decrease of ceruloplasmin activity in serum (by 97 %) and hematological changes.For estimation of thyroid hormone metabolism, the concentrations of total and free thyroxine (T-4) and triiodothyronine (T-3) in serum and the activity of hepatic 5'monodeiodinase (5'D) were determined. Copper-deficient rats had an increased concentration of T-3 in serum, whereas the concentrations of total and free T-4 as well as the activity of hepatic 5'D were not different compared with copper-adequate control rats. Therefore, the study shows that copper deficiency has only slight effects on thyroid hormone metabolism in growing rats.

Harvard Citation style: Kralik, A., Kirchgeßner, M. and Eder, K. (1996) Concentrations of thyroid hormones in serum and activity of hepatic 5'monodeiodinase in copper-deficient rats, Zeitschrift für Ernährungswissenschaft, 35(3), pp. 288-291. https://doi.org/10.1007/BF01625694

APA Citation style: Kralik, A., Kirchgeßner, M., & Eder, K. (1996). Concentrations of thyroid hormones in serum and activity of hepatic 5'monodeiodinase in copper-deficient rats. Zeitschrift für Ernährungswissenschaft. 35(3), 288-291. https://doi.org/10.1007/BF01625694