Journalartikel

Jahr der Veröffentlichung: 2002

Seiten: 125-132

Zeitschrift: Trace Elements and Electrolytes

Bandnummer: 19

Heftnummer: 3

ISSN: 0946-2104

Verlag: Dustri-Verlag

Abstract: 
Recent studies demonstrated that iron overload of the body by feeding diets with excessive iron concentrations causes a hyperlipidemia in model animals. To date, the effect of dietary fatty acids in the development of iron-induced hyperlipidemia has not been elucidated. The present study, therefore, was carried out to investigate whether the dietary fat influences the effects of iron overload on the concentrations of plasma lipids. An experiment with 40 rats was carried out which were allotted to 4 groups. According to a bifactorial design, diets with 2 different iron concentrations (adequate iron: 50 mg per kg; high iron: 500 mg per kg) and 2 different sources of fat (lard vs. fish oil), at a level of 100 g per kg diet, were used. The diets were fed over a period of 12 weeks; the feed intake was standardized by a restricted feeding system. Feeding the high iron diets increased hepatic iron concentrations by 20% relative to feeding iron adequate diets. Hepatic concentrations of thiobarbituric acid-reactive substances and tocopherols were not different between rats fed with adequate iron diets and high-iron diets, meaning that feeding the high-iron diets did not produce oxidative stress in the rats. However, rats fed the high-iron diets had higher concentrations of cholesterol in plasma than rats fed with the iron-adequate diets. The magnitude of this effect was similar in rats fed the lard diets and in rats fed the fish oil diets. In contrast, the concentrations of triglycerides was raised in the rats fed only with high iron-diets and lard but not in the rats fed the fish oil diets. The excretion of cholesterol via the feces and concentrations of the thyroid hormones in plasma were measured because they are important determinants of the plasma cholesterol concentration. The results of those measurements suggest that neither a reduced excretion of cholesterol via feces nor hypothyroidism is responsible for hypercholesterolemia caused by iron overload. The study, in conclusion, shows that the development of a hypercholesterolemia by feeding high-iron diets is independent of the dietary fat and might not be caused by iron-induced lipid peroxidation.

Harvard-Zitierstil: Brandsch, C. and Eder, K. (2002) Effects of high-iron diets on plasma lipid concentrations in rats fed lard or fish oil, Trace Elements and Electrolytes, 19(3), pp. 125-132

APA-Zitierstil: Brandsch, C., & Eder, K. (2002). Effects of high-iron diets on plasma lipid concentrations in rats fed lard or fish oil. Trace Elements and Electrolytes. 19(3), 125-132.