Journal article

Publication year: 2018

Pages: 4070935-

Journal: Oxidative Medicine and Cellular Longevity

Volume number: 2018

ISSN: 1942-0994

Open access status: Hybrid

DOI Link: https://doi.org/10.1155/2018/4070935

Publisher: Wiley

Abstract: 
Aging represents a major risk factor for developing neurodegenerative diseases such as Alzheimer's disease (AD). As components of the Mediterranean diet, olive polyphenols may play a crucial role in the prevention of AD. Since mitochondrial dysfunction acts as a final pathway in both brain aging and AD, respectively, the effects of a mixture of highly purified olive secoiridoids were tested on cognition and ATP levels in a commonly used mouse model for brain aging. Over 6 months, female NMRI mice (12 months of age) were fed with a blend containing highly purified olive secoiridoids (POS) including oleuropein, hydroxytyrosol and oleurosid standardized for 50 mg oleuropein/kg diet (equivalent to 13.75 mg POS/kg b.w.) or the study diet without POS as control. Mice aged 3 months served as young controls. Behavioral tests showed deficits in cognition in aged mice. Levels of ATP and mRNA levels of NADH-reductase, cytochrome-c-oxidase, and citrate synthase were significantly reduced in the brains of aged mice indicating mitochondrial dysfunction. Moreover, gene expression of Sirt1, CREB, Gap43, and GPx-1 was significantly reduced in the brain tissue of aged mice. POS-fed mice showed improved spatial working memory. Furthermore, POS restored brain ATP levels in aged mice which were significantly increased. Our results show that a diet rich in purified olive polyphenols has positive long-term effects on cognition and energy metabolism in the brain of aged mice.

Harvard Citation style: Reutzel, M., Grewal, R., Silaidos, C., Zotzel, J., Marx, S., Tretzel, J., et al. (2018) Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice, Oxidative Medicine and Cellular Longevity, 2018, p. 4070935. https://doi.org/10.1155/2018/4070935

APA Citation style: Reutzel, M., Grewal, R., Silaidos, C., Zotzel, J., Marx, S., Tretzel, J., & Eckert, G. (2018). Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice. Oxidative Medicine and Cellular Longevity. 2018, 4070935. https://doi.org/10.1155/2018/4070935