Journal article

Publication year: 2004

Pages: 243-246

Journal: International Journal for Vitamin and Nutrition Research

Volume number: 74

Issue number: 4

ISSN: 0300-9831

DOI Link: https://doi.org/10.1024/0300-9831.74.4.243

Publisher: Hogrefe

Abstract: 
The objective of this study was to determine the effects of cis-9, trans-11 and trans-10, cis-12 CLA on the Delta4-desaturation process in HepG2 cells. Experiments were conducted in which HepG2 cells were incubated with 25 mumol/L of those fatty acids and the concentrations of (n-6) and (n-3) polyunsaturated fatty acids in phosphatidyl choline and phosphatidyl ethanolamine were determined. In the presence of eicosapentaenoic acid, cells treated with trans-10, cis-12 CLA had a lower ratio of docosahexaenoic acid [22:6 (n-3)], the product of Delta4-desaturation, to docosapentaenoic acid [22:5 (n-3)], the substrate of Delta4-desaturation in both phospholipids, than control cells or cells treated with cis-9, trans-11 CLA (p < 0.05). This suggests that trans-10, cis-12 CLA Suppresses the Delta4-desaturation process in HepG2 cells.

Harvard Citation style: Slomma, N., Becker, K. and Eder, K. (2004) The effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acids on Δ4-desaturation in HepG2 cells, International Journal for Vitamin and Nutrition Research, 74(4), pp. 243-246. https://doi.org/10.1024/0300-9831.74.4.243

APA Citation style: Slomma, N., Becker, K., & Eder, K. (2004). The effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acids on Δ4-desaturation in HepG2 cells. International Journal for Vitamin and Nutrition Research. 74(4), 243-246. https://doi.org/10.1024/0300-9831.74.4.243