Journal article

Publication year: 1998

Pages: 10-15

Journal: Amyloid: The Journal of Protein Folding Disorders

Volume number: 5

Issue number: 1

ISSN: 1350-6129

DOI Link: https://doi.org/10.3109/13506129809007284

Publisher: Taylor and Francis Group

Abstract: 
beta-amyloid peptide (A beta) and Several A beta-fragments decrease the fluidity of human cortex membranes in a concentration dependent fashion. The effect of A beta an membrane fluidity increases with peptide length, is mast pronounced for A beta 1-43 and can be seen at concentrations as low as 100 nmol/l. While the fragment A beta 25-35 is active, scrambled peptide (A beta 35-25) when investigated under similar conditions shows no effects on membrane fluidity. The effect of A beta peptides on fluidity of the phospholipid bilayer is more pronounced in the hydrocarbon core (labeled with the fluorescence probe 1,6-diphenylhexa-1,3,5-triene) than in the region of the hydrophilic heads (labeled with the fluorescence probe 1-[4'-(trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene). It if suggested that the effect of A beta on neuronal membranes is probably a major initial mechanism in a cascade of events finally leading to neurotoxicity and cell death in Alzheimer's disease.

Harvard Citation style: Müller, W., Eckert, G., Scheuer, K., Cairns, N., Maras, A. and Gattaz, W. (1998) Effects of β-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of Aβ1-42 and Aβ1-43, Amyloid: The Journal of Protein Folding Disorders, 5(1), pp. 10-15. https://doi.org/10.3109/13506129809007284

APA Citation style: Müller, W., Eckert, G., Scheuer, K., Cairns, N., Maras, A., & Gattaz, W. (1998). Effects of β-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of Aβ1-42 and Aβ1-43. Amyloid: The Journal of Protein Folding Disorders. 5(1), 10-15. https://doi.org/10.3109/13506129809007284