Journalartikel

Jahr der Veröffentlichung: 1995

Seiten: 269-275

Zeitschrift: Journal of Animal Physiology and Animal Nutrition

Bandnummer: 73

Heftnummer: 5

ISSN: 0931-2439

DOI Link: https://doi.org/10.1111/j.1439-0396.1995.tb00427.x

Verlag: Wiley

Abstract: 
The effect of manganese deficiency on parameters of thyroid-hormone metabolism in rats The effect of manganese deficiency on parameters of thyroid-hormone metabolism was examined in two experiments with 24 male, weanling, Sprague Dawley rats per experiment. The animals were fed a semisynthetic casein-based diet containing either 0.2 mg Mn/kg (manganese deficient diet) or 40 mg Mn/kg (control diet). The activity of arginase in liver was chosen as the criterion for determining the manganese status of the rats, and was clearly lowered in both experiments by manganese deficiency. While being unchanged in experiment 1, the live weight of the manganese-deficient animals at the end of experiment 2 was significantly reduced in contrast to control. The concentration of T-3 in the serum of the deficient animals was decreased in experiment 1, while tending to be increased in experiment 2. The concentration of T-4 in the serum of the manganese-deficient rats was significantly decreased in both experiments (experiment 1: -18 %; experiment 2: -31 %). The concentration of free T-4 in serum was not changed by manganese deficiency. The activity of hepatic deiodinase was increased in both experiments in manganese-deficient rats (experiment 1: 35 %, ns; experiment 2: 48 %). The results of this investigation show a potential role for manganese in thyroid-hormone metabolism.

Harvard-Zitierstil: Kralik, A., Kirchgeßner, M. and Eder, K. (1995) Einfluß einer defizitären Manganversorgung auf den Stoffwechsel der Schilddrüsenhormone bei der Ratte, Journal of Animal Physiology and Animal Nutrition, 73(5), pp. 269-275. https://doi.org/10.1111/j.1439-0396.1995.tb00427.x

APA-Zitierstil: Kralik, A., Kirchgeßner, M., & Eder, K. (1995). Einfluß einer defizitären Manganversorgung auf den Stoffwechsel der Schilddrüsenhormone bei der Ratte. Journal of Animal Physiology and Animal Nutrition. 73(5), 269-275. https://doi.org/10.1111/j.1439-0396.1995.tb00427.x