Journalartikel

Jahr der Veröffentlichung: 2007

Seiten: 387-392

Zeitschrift: Annals of Nutrition and Metabolism

Bandnummer: 51

Heftnummer: 4

ISSN: 0250-6807

DOI Link: https://doi.org/10.1159/000107720

Verlag: Karger Publishers

Abstract: 
Background: Recently, it has been shown that dietary lupin protein lowers plasma triglyceride concentrations in rats. In this study, we investigated the hypothesis that this effect is due to a downregulation of sterol regulatory element-binding protein (SREBP)-1c, a transcription factor that regulates the expression of lipogenic enzymes in the livers of rats. Methods: Two groups of 12 rats each were fed semisynthetic diets containing 200 g/kg of either casein (control group) or lupin protein from Lupinus albus for 22 days.
Results: Rats fed the diet containing lupin protein had lower concentrations of triglycerides in the liver, plasma and VLDL + chylomicrons (p < 0.05). The concentration of protein in VLDL + chylomicrons was also lower in rats fed lupin protein than in rats fed casein (p < 0.05). The mRNA concentrations of SREBP-1c and fatty acid synthase in the liver were lower in rats fed lupin protein than in rats fed casein (p < 0.05). The mRNA concentrations of lipoprotein lipase in the liver did not differ between both groups of rats.
Conclusion: This study confirms that a protein isolated from L. albus is strongly hypotriglyceridemic in rats. It is shown for the first time that this effect is at least in part due to a downregulation of SREBP-1c in the liver which in turn leads to a reduction in hepatic fatty acid synthesis. Copyright (c) 2007 S. Karger AG, Basel.

Harvard-Zitierstil: Spielmann, J., Shukla, A., Brandsch, C., Hirche, F., Stangl, G. and Eder, K. (2007) Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c, Annals of Nutrition and Metabolism, 51(4), pp. 387-392. https://doi.org/10.1159/000107720

APA-Zitierstil: Spielmann, J., Shukla, A., Brandsch, C., Hirche, F., Stangl, G., & Eder, K. (2007). Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c. Annals of Nutrition and Metabolism. 51(4), 387-392. https://doi.org/10.1159/000107720