Journalartikel

Jahr der Veröffentlichung: 2007

Zeitschrift: Lipids in Health and Disease

Bandnummer: 6

ISSN: 1476-511X

DOI Link: https://doi.org/10.1186/1476-511X-6-6

Verlag: BioMed Central

Abstract: 
Background: Feeding oxidized fats causes activation of peroxisome proliferator-activated receptor alpha (PPAR alpha) in the liver of rats. However, whether feeding oxidized fat during pregnancy also results in activation of PPAR alpha in fetal liver is unknown. Thus, this study aimed to explore whether feeding oxidized fat during pregnancy causes a PPAR alpha response in fetal liver. Two experiments with pregnant rats which were administered three different diets (control; oxidized fat; clofibrate as positive control) in a controlled feeding regimen during either late pregnancy (first experiment) or whole pregnancy (second experiment) were performed.
Results: In both experiments pregnant rats treated with oxidized fat or clofibrate had higher relative mRNA concentrations of the PPAR alpha-responsive genes acyl-CoA oxidase (ACO), cytochrome P-450 4A1 (CYP4A1), L-type carnitin- palmitoyl transferase I (L-CPT I), medium-chain acyl-CoA dehydrogenase (MCAD), and long-chain acyl-CoA dehydrogenase (LCAD) in the liver than control rats (P < 0.05). In addition, in both experiments fetuses of the oxidized fat group and the clofibrate group also had markedly higher relative mRNA concentrations of ACO, CYP4A1, CPT I, MCAD, and LCAD in the liver than those of the control group (P < 0.05), whereas the relative mRNA concentrations of PPAR alpha, SREBP-1c, and FAS did not differ between treatment groups. In the second experiment treatment with oxidized fat also reduced triacylglycerol concentrations in the livers of pregnant rats and fetuses (P < 0.05).
Conclusion: The present study demonstrates for the first time that components of oxidized fat with PPAR alpha activating potential are able to induce a PPAR alpha response in the liver of fetuses. Moreover, the present study shows that feeding oxidized fat during whole pregnancy, but not during late pregnancy, lowers triacylglycerol concentrations in fetal livers.

Harvard-Zitierstil: Ringseis, R., Gutgesell, A., Dathe, C., Brandsch, C. and Eder, K. (2007) Feeding oxidized fat during pregnancy up-regulates expression of PPARα-responsive genes in the liver of rat fetuses, Lipids in Health and Disease, 6, Article 6. https://doi.org/10.1186/1476-511X-6-6

APA-Zitierstil: Ringseis, R., Gutgesell, A., Dathe, C., Brandsch, C., & Eder, K. (2007). Feeding oxidized fat during pregnancy up-regulates expression of PPARα-responsive genes in the liver of rat fetuses. Lipids in Health and Disease. 6, Article 6. https://doi.org/10.1186/1476-511X-6-6