Journal article

Publication year: 2013

Pages: 1135-1136

Journal: Natural Product Communications

Volume number: 8

Issue number: 8

ISSN: 1934-578X

DOI Link: https://doi.org/10.1177/1934578X1300800827

Publisher: SAGE Publications

Abstract: 
In our study, the binding affinities of selected natural products towards Para, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996-3.63 mu g/mL).

Harvard Citation style: Munigunti, R., Becker, K., Brun, R. and Calderon, A. (2013) Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards PfTrxR and PfGR, Natural Product Communications, 8(8), pp. 1135-1136. https://doi.org/10.1177/1934578X1300800827

APA Citation style: Munigunti, R., Becker, K., Brun, R., & Calderon, A. (2013). Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards PfTrxR and PfGR. Natural Product Communications. 8(8), 1135-1136. https://doi.org/10.1177/1934578X1300800827