Journalartikel

Jahr der Veröffentlichung: 2001

Seiten: 643-646

Zeitschrift: Science

Bandnummer: 291

Heftnummer: 5504

ISSN: 0036-8075

eISSN: 1095-9203

DOI Link: https://doi.org/10.1126/science.291.5504.643

Verlag: American Association for the Advancement of Science

Abstract: 
The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate the absence of glutathione reductase in Drosophila melanogaster, identify a new type of thioredoxin reductase, and provide evidence that a thioredoxin system supports GSSG reduction. Our data suggest that antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.

Harvard-Zitierstil: Kanzok, S., Fechner, A., Bauer, H., Ulschmid, J., Müller, H., Botella-Munoz, J., et al. (2001) Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster, Science, 291(5504), pp. 643-646. https://doi.org/10.1126/science.291.5504.643

APA-Zitierstil: Kanzok, S., Fechner, A., Bauer, H., Ulschmid, J., Müller, H., Botella-Munoz, J., Schneuwly, S., Schirmer, R., & Becker, K. (2001). Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. Science. 291(5504), 643-646. https://doi.org/10.1126/science.291.5504.643