Journal article

Publication year: 2000

Pages: 132-138

Journal: The Journal of Nutritional Biochemistry

Volume number: 11

Issue number: 3

ISSN: 0955-2863

DOI Link: https://doi.org/10.1016/S0955-2863(99)00084-4

Publisher: Elsevier

Abstract: 
The present study was performed to investigate the effect of zinc deficiency on the activities of lipoprotein lipase in postheparin serum and tissues of rats fed diets containing either coconut ail or fish oil as dietary fat, using a bifactorial experimental design. To ensure an adequate food intake, all the ruts were force-fed by gastric tube Experimental diets contained either 0.8 mg zinc/kg (zinc-deficient diets) or 40 mg zinc/kg (zinc-adequate diets). The effects of zinc deficiency on the activities of lipoprotein lipase in postheparin serum and postprandial triglyceride concentrations and distribution of apolipoproteins in serum lipoproteins depended on the type of dietary fat. Zinc-deficient rats fed the coconut oil diet exhibited a reduced activity of lipoprotein lipase in postheparin serum and adipose tissue markedly increased concentrations of triglycerides in serum, and a markedly reduced content of apolipoprotein C in triglyceride-rich lipoproteins and high density lipoproteins compared with zinc-adequate rats fed coconut oil. By contrast, zinc-deficient rats fed the fish oil diet did not exhibit reduced activities of lipoprotein lipase in postheparin serum and adipose tissue and increased concentrations of serum lipids compared with zinc-adequate rats fed the fish oil diet. This study suggests that a reduced activity of lipoprotein activity might contribute to increased postprandial concentrations of serum triglycerides observed in zinc-deficient animals. However, it also demonstrates that the effects of zinc defficiency on lipoprotein metabolism are influenced by dietary fatty acids. (C) Elsevier Science Inc. 2000. All rights reserved.

Harvard Citation style: Kettler, S., Eder, K., Kettler, A. and Kirchgeßner, M. (2000) Zinc deficiency and the activities of lipoprotein lipase in plasma and tissues of rats force-fed diets with coconut oil or fish oil, The Journal of Nutritional Biochemistry, 11(3), pp. 132-138. https://doi.org/10.1016/S0955-2863(99)00084-4

APA Citation style: Kettler, S., Eder, K., Kettler, A., & Kirchgeßner, M. (2000). Zinc deficiency and the activities of lipoprotein lipase in plasma and tissues of rats force-fed diets with coconut oil or fish oil. The Journal of Nutritional Biochemistry. 11(3), 132-138. https://doi.org/10.1016/S0955-2863(99)00084-4