Journal article

Publication year: 2007

Pages: 1196-1205

Journal: British Journal of Nutrition

Volume number: 97

Issue number: 6

ISSN: 0007-1145

DOI Link: https://doi.org/10.1017/S0007114507685183

Publisher: Cambridge University Press

Abstract: 
Trans-fatty acid intake is associated with an increased risk of CHD and diabetes. The effects of single trans-fatty acid isomers are largely unexplored. The present study examined the effects of a 6-week supplementation with two trans-18:1 isomers (trans- I I and trans- 12) in human subjects on immune cells, several inflammatory and immunological biomarkers (for example, IL, TNF alpha, C-reactive protein, adiponectin, intercellular adhesion molecule-1, prostacyclin, phagocytic process). Following a 2-week adaptation period without supplements, the test group (n 12) received vaccenic acid (trans-11-18:1) and trans-12-18:1 in equal amounts (6-0 g/d) for 6 weeks. The control group (n 12) consumed an oil without trans-fatty acids and conjugated linoleic acids (CLA). Samples were collected at the end of both periods. Trans-11-and trans-12-18: I were significantly increased in cellular lipids. The endogenous synthesis of cis-9, trans-11-CLA from trans-11-18:1 was demonstrated via increased CLA in cellular lipids of the test group. Generally, trans-isomer supplementation did not affect either inflammatory biomarkers (for example, IL-6, IL-8, TNF alpha) or immune function (for example, phagocytosis) during the present study. The dietary supplementation of trans-11- and trans-12-18:1 (6g/d) and their accumulation in leucocytes had no effects on biomarkers of inflammation and immune function. However, because of the limited data on the safety of trans-fatty acid intake and effects of individual trans isomers on human health (for example, trans-9-18 : 1, trans- 10-18:1) at present, it is prudent to reduce trans-fat intake in general.

Harvard Citation style: Kuhnt, K., Kraft, J., Vogelsang, H., Eder, K., Kratzsch, J. and Jahreis, G. (2007) Dietary supplementation with trans-11-and trans-12-18 : 1 increases cis-9, trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation, British Journal of Nutrition, 97(6), pp. 1196-1205. https://doi.org/10.1017/S0007114507685183

APA Citation style: Kuhnt, K., Kraft, J., Vogelsang, H., Eder, K., Kratzsch, J., & Jahreis, G. (2007). Dietary supplementation with trans-11-and trans-12-18 : 1 increases cis-9, trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation. British Journal of Nutrition. 97(6), 1196-1205. https://doi.org/10.1017/S0007114507685183