Journal article

Publication year: 2003

Pages: 246-250

Journal: Redox Report: Communications in Free Radical Research

Volume number: 8

Issue number: 5

ISSN: 1351-0002

eISSN: 1743-2928

Open access status: Bronze

DOI Link: https://doi.org/10.1179/135100003225002844

Publisher: Taylor and Francis Group

Abstract: 
Over the last few years, an increasing number of different functions have been ascribed to small redox-active proteins like thioredoxins (Trx) and glutaredoxins (Grx). These functions include redox regulation of transcription and translation, antioxidant defence, involvement in protein folding and cellular signalling, and reduction of ribonucleotide reductase. In the malarial parasite Plasmodium falciparum, a classical Trx and a typical Grx have been described as well as a number of Trx- and Grx-like proteins including monothiol glutaredoxins. Furthermore, plasmoredoxin, a redox-active protein related to Trx, has been characterized; plasmoredoxin is unique for malarial parasites, therefore having great potential as diagnostic tool. In this minireview, we summarize the current knowledge on members of the thioredoxin superfamily and their function in the malarial parasite P. falciparum.

Harvard Citation style: Rahlfs, S., Nickel, C., Deponte, M., Schirmer, R. and Becker, K. (2003) Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism, Redox Report: Communications in Free Radical Research, 8(5), pp. 246-250. https://doi.org/10.1179/135100003225002844

APA Citation style: Rahlfs, S., Nickel, C., Deponte, M., Schirmer, R., & Becker, K. (2003). Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism. Redox Report: Communications in Free Radical Research. 8(5), 246-250. https://doi.org/10.1179/135100003225002844