Journal article

Publication year: 2013

Journal: Acta Veterinaria Scandinavica

Volume number: 55

ISSN: 0044-605X

Open access status: Gold

DOI Link: https://doi.org/10.1186/1751-0147-55-18

Publisher: BioMed Central

Abstract: 
Background: In pigs, enteric infections and the development of gut disorders such as diarrhoea are commonly observed, particularly after weaning. The present study investigated the hypothesis that feeding a grape seed and grape marc extract (GSGME) as a dietary supplement has the potential to suppress the inflammatory process in the small intestine of pigs by modulating the activities of NF-kappa B and Nrf2 due to its high content of flavonoids.Methods: Twenty-four crossbred, 6 weeks old pigs were randomly assigned to 2 groups of 12 animals each and fed nutritionally adequate diets without or with 1% GSGME for 4 weeks.Results: Pigs administered GSGME had a lower transactivation of NF-kappa B and Nrf2 and a lower expression of various target genes of these transcription factors in the duodenal mucosa than control pigs (P < 0.05). Concentrations of a-tocopherol and thiobarbituric acid reactive substances (TBARS) in liver and plasma and total antioxidant capacity of plasma and relative mRNA abundances of NF-kappa B and Nrf2 target genes in the liver did not differ between the two groups. However, the ratio of villus height: crypt depth and the gain: feed ratio was higher in the pigs fed GSGME than in control pigs (P < 0.05).Conclusions: This study shows that dietary supplementation of a polyphenol rich GSGME suppresses the activity of NF-kappa B in the duodenal mucosa of pigs and thus might provide a useful dietary strategy to inhibit inflammation in the gut frequently occurring in pigs. Feeding GSGME did not influence vitamin E status and the antioxidant system of the pigs but improved the gain: feed ratio. In overall, the study suggests that polyphenol-rich plant extracts such GSGME could be useful feed supplements in pig nutrition, in order to maintain animal health and improve performance.

Harvard Citation style: Gessner, D., Fiesel, A., Most, E., Dinges, J., Wen, G., Ringseis, R., et al. (2013) Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-kappa B and Nrf2 in the duodenal mucosa of pigs, Acta Veterinaria Scandinavica, 55, Article 18. https://doi.org/10.1186/1751-0147-55-18

APA Citation style: Gessner, D., Fiesel, A., Most, E., Dinges, J., Wen, G., Ringseis, R., & Eder, K. (2013). Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-kappa B and Nrf2 in the duodenal mucosa of pigs. Acta Veterinaria Scandinavica. 55, Article 18. https://doi.org/10.1186/1751-0147-55-18