Contribution in an anthology

Appeared in: Peroxiredoxin Systems : Structures and Functions

Editor list: Flohe, L; Harris, JR

Publication year: 2007

Pages: 219-229

ISBN: 978-1-4020-6050-2

eISBN: 978-1-4020-6051-9

DOI Link: https://doi.org/10.1007/978-1-4020-6051-9_10

Title of series: Subcellular Biochemistry

Number in series: 44

Abstract: 

Cellular redox metabolism is considered to be involved in the pathophysiology of diseases caused by protozoal parasites such as Toxoplasma, Trypanosoma, Leishmania, and Plasmodia. Redox reactions furthermore are thought to play a major role in the action of and the resistance to some clinically used antiparasitic drugs. Interestingly, in malarial parasites, the antioxidant enzymes catalase and glutathione peroxidase are absent which indicates a crucial role of the thioredoxin system in redox control. Besides a glutathione peroxidase-like thioredoxin peroxidase and a glutathione S-transferase with slight peroxidase activity, Plasmodium falciparum (the causative agent of tropical malaria) possesses four classical peroxiredoxins: Two peroxiredoxins of the typical 2-Cys Prx class, one 1-Cys peroxiredoxin with homology to the atypical 2-Cys Prx class, and a peroxiredoxin of the 1-Cys Prx class have been identified and partially characterized.

In our article we give an introduction to redox-based drug development strategies against protozoal parasites and summarize the present knowledge on peroxiredoxin systems in Plasmodium

Harvard Citation style: Deponte, M., Rahlfs, S. and Becker, K. (2007) Peroxiredoxin Systems of Protozoal Parasites, in Flohe, L. and Harris, J. (eds.) Peroxiredoxin Systems : Structures and Functions. Dordrecht: Springer, pp. 219-229. https://doi.org/10.1007/978-1-4020-6051-9_10

APA Citation style: Deponte, M., Rahlfs, S., & Becker, K. (2007). Peroxiredoxin Systems of Protozoal Parasites. In Flohe, L., & Harris, J. (Eds.), Peroxiredoxin Systems : Structures and Functions (pp. 219-229). Springer. https://doi.org/10.1007/978-1-4020-6051-9_10