Journal article

Publication year: 2012

Pages: 360-363

Journal: British Journal of Nutrition

Volume number: 107

Issue number: 3

ISSN: 0007-1145

DOI Link: https://doi.org/10.1017/S0007114511002984

Publisher: Cambridge University Press

Abstract: 
There is increasing interest in the gene-regulatory activities of isothiocyanates and flavonoids in human skin. Nrf2 agonists, such as isothiocyanate sulforaphane (SFN), have been shown to promote chemopreventive effects in skin both in vitro and in vivo. Recent data indicate that different secondary plant compounds may either antagonise or enhance SFN-induced Nrf2 activation. We therefore studied the interactions of a flavonoid, cyanidin and the potent Nrf2 inductor SFN in cultured human keratinocytes (HaCaT cells). We observed that cyanidin does not induce the activation of Nrf2 and its target genes, gamma-glutamylcysteine synthetase (gamma GCS), NAD(P)H: quinone oxidoreductase 1 and haem oxygenase-1 in HaCaT cells. Furthermore, SFN-mediated Nrf2 activation and its target gene expression were not further enhanced by the co-application of SFN with cyanidin.

Harvard Citation style: Ernst, I., Wagner, A., Huebbe, P. and Rimbach, G. (2012) Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes, British Journal of Nutrition, 107(3), pp. 360-363. https://doi.org/10.1017/S0007114511002984

APA Citation style: Ernst, I., Wagner, A., Huebbe, P., & Rimbach, G. (2012). Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes. British Journal of Nutrition. 107(3), 360-363. https://doi.org/10.1017/S0007114511002984