Journal article

Publication year: 2012

Pages: 523-530

Journal: Pharmacological Research

Volume number: 65

Issue number: 5

ISSN: 1043-6618

DOI Link: https://doi.org/10.1016/j.phrs.2012.02.007

Publisher: Elsevier

Abstract: 
The anti-inflammatory properties of the flavonol quercetin have been intensively investigated using in vitro cell systems and are to a great extent reflected by changes in the expression of inflammatory markers. However, information relating to the degree at which quercetin affects inflammatory gene expression in vivo is limited. Recently, micro RNAs (miRNAs) have been identified as powerful post-transcriptional gene regulators. The effect of quercetin on miRNA regulation in vivo is largely unknown. Laboratory mice were fed for six weeks with control or quercetin enriched high fat diets and biomarkers of inflammation as well as hepatic levels of miRNAs previously involved in inflammation (miR-125b) and lipid metabolism (miR-122) were determined. We found lower mRNA steady state levels of the inflammatory genes interleukin 6, C-reactive protein, monocyte chemoattractant protein 1, and acyloxyacyl hydrolase in quercetin fed mice. In addition we found evidence for an involvement of redox factor 1, a modulator of nuclear factor kappa B signalling, on the attenuation of inflammatory gene expression mediated by dietary quercetin. Furthermore, the results demonstrate that hepatic miR-122 and miR-125b concentrations were increased by dietary quercetin supplementation and may therefore contribute to the gene-regulatory activity of quercetin in vivo. (C) 2012 Elsevier Ltd. All rights reserved.

Harvard Citation style: Boesch-Saadatmandi, C., Wagner, A., Wolffram, S. and Rimbach, G. (2012) Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b, Pharmacological Research, 65(5), pp. 523-530. https://doi.org/10.1016/j.phrs.2012.02.007

APA Citation style: Boesch-Saadatmandi, C., Wagner, A., Wolffram, S., & Rimbach, G. (2012). Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b. Pharmacological Research. 65(5), 523-530. https://doi.org/10.1016/j.phrs.2012.02.007