Journal article
Authors list: Wagner, AE; Terschluesen, AM; Rimbach, G
Publication year: 2013
Pages: 964539-
Journal: Oxidative Medicine and Cellular Longevity
Volume number: 2013
ISSN: 1942-0900
DOI Link: https://doi.org/10.1155/2013/964539
Publisher: Wiley
Abstract:
A high intake of brassica vegetables may be associated with a decreased chronic disease risk. Health promoting effects of Brassicaceae have been partly attributed to glucosinolates and in particular to their hydrolyzation products including isothiocyanates. In vitro and in vivo studies suggest a chemopreventive activity of isothiocyanates through the redox-sensitive transcription factor Nrf2. Furthermore, studies in cultured cells, in laboratory rodents, and also in humans support an anti-inflammatory effect of brassica-derived phytochemicals. However, the underlying mechanisms of how these compounds mediate their health promoting effects are yet not fully understood. Recent findings suggest that brassica-derived compounds are regulators of epigenetic mechanisms. It has been shown that isothiocyanates may inhibit histone deacetylase transferases and DNAmethyltransferases in cultured cells. Only a few papers have dealt with the effect of brassica-derived compounds on epigenetic mechanisms in laboratory animals, whereas data in humans are currently lacking. The present reviewaims to summarize the current knowledge regarding the biological activities of brassica-derived phytochemicals regarding chemopreventive, anti-inflammatory, and epigenetic pathways.
Citation Styles
Harvard Citation style: Wagner, A., Terschluesen, A. and Rimbach, G. (2013) Health Promoting Effects of Brassica-Derived Phytochemicals: From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation, Oxidative Medicine and Cellular Longevity, 2013, p. 964539. https://doi.org/10.1155/2013/964539
APA Citation style: Wagner, A., Terschluesen, A., & Rimbach, G. (2013). Health Promoting Effects of Brassica-Derived Phytochemicals: From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation. Oxidative Medicine and Cellular Longevity. 2013, 964539. https://doi.org/10.1155/2013/964539
