Journalartikel

Jahr der Veröffentlichung: 2019

Seiten: 158-

Zeitschrift: Marine Drugs

Bandnummer: 17

Heftnummer: 3

ISSN: 1660-3397

Open Access Status: Gold

DOI Link: https://doi.org/10.3390/md17030158

Verlag: MDPI

Abstract: 
Sponges are a well-known bioresource for bioactive compounds. In this study, antibacterial activity-guided fractionation of the extract from an Indonesian marine Dactylospongia elegans sponge led to the discovery of four merosesquiterpenoids, namely, a new sesquiterpenoid aminoquinone nakijiquinone V (1), along with illimaquinone (2), smenospongine (3), and dyctioceratine C (4). The structure of compound 1 was elucidated by 1D and 2D NMR as well as by LC-HRESIMS data analysis. Compounds 2-4 showed moderate to low antimicrobial activity against Bacillus megaterium DSM32 with a minimum inhibitory concentration (MIC) of 32 g/mL, 32 g/mL, and 64 g/mL, respectively. Furthermore, compounds 2 and 3 both inhibited Micrococcus luteus ATCC 4698 with a MIC of 32 g/mL. In conclusion, the isolated merosesquiterpenoids, which are known for their cytotoxic effects, showed antibacterial activity and prompt future structure activity relationship (SAR) studies concerning the various bioactivities observed for this group of natural products.

Harvard-Zitierstil: Balansa, W., Mettal, U., Wuisan, Z., Plubrukarn, A., Ijong, F., Liu, Y., et al. (2019) A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge, Marine Drugs, 17(3), p. 158. https://doi.org/10.3390/md17030158

APA-Zitierstil: Balansa, W., Mettal, U., Wuisan, Z., Plubrukarn, A., Ijong, F., Liu, Y., & Schäberle, T. (2019). A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge. Marine Drugs. 17(3), 158. https://doi.org/10.3390/md17030158