Journal article

Publication year: 2015

Pages: 2505-2509

Journal: Journal of Natural Products

Volume number: 78

Issue number: 10

ISSN: 0163-3864

DOI Link: https://doi.org/10.1021/acs.jnatprod.5b00175

Publisher: American Chemical Society

Abstract: 
The new compound precorallopyronin A is a stable precursor in the biosynthesis of the antibiotic corallopyronin A. This natural product was isolated from the producer strain Corallococcus coralloides B035. Together with various semisynthetically obtained corallopyronin A derivatives its antibacterial effects were evaluated. In combination with an X-ray crystallization model limitations of derivatization possibilities were revealed. The antibiotic potential of the novel precorallopyronin A is comparable to that of the structurally more complex corallopyronin A, which highlights that the additional chiral center is not essential for activity.

Harvard Citation style: Schäberle, T., Schmitz, A., Zocher, G., Schiefer, A., Kehraus, S., Neu, E., et al. (2015) Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives, Journal of Natural Products, 78(10), pp. 2505-2509. https://doi.org/10.1021/acs.jnatprod.5b00175

APA Citation style: Schäberle, T., Schmitz, A., Zocher, G., Schiefer, A., Kehraus, S., Neu, E., Roth, M., Vassylyev, D., Stehle, T., Bierbaum, G., Hoerauf, A., Pfarr, K., & König, G. (2015). Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives. Journal of Natural Products. 78(10), 2505-2509. https://doi.org/10.1021/acs.jnatprod.5b00175