Journal article

Publication year: 2014

Pages: 159-163

Journal: Journal of Natural Products

Volume number: 77

Issue number: 1

ISSN: 0163-3864

DOI Link: https://doi.org/10.1021/np400740u

Publisher: American Chemical Society

Abstract: 
The myxobacterium Corallococcus coralloides is the producer of the antibiotic compound corallopyronin A, which is currently in preclinical evaluation. To obtain suitable amounts of this antibiotic, the production strain C. coralloides B035 was cultured in large volumes, which in the addition to the isolation of the target molecule facilitates the detection of additional metabolites of this myxobacterial strain (corallorazines A C). Corallorazine A is a new structural type of dipeptide composed of a dehydroalanine and a glycine moiety that are linked via a semiaminal bond, thus forming a piperazine ring. The latter is further connected via an amide bond to an unusual aliphatic acyl chain.

Harvard Citation style: Schmitz, A., Kehraus, S., Schäberle, T., Neu, E., Almeida, C., Roth, M., et al. (2014) Corallorazines from the Myxobacterium Corallococcus coralloides, Journal of Natural Products, 77(1), pp. 159-163. https://doi.org/10.1021/np400740u

APA Citation style: Schmitz, A., Kehraus, S., Schäberle, T., Neu, E., Almeida, C., Roth, M., & König, G. (2014). Corallorazines from the Myxobacterium Corallococcus coralloides. Journal of Natural Products. 77(1), 159-163. https://doi.org/10.1021/np400740u