Journalartikel

Jahr der Veröffentlichung: 2013

Seiten: 1363-1371

Zeitschrift: ChemBioChem

Bandnummer: 14

Heftnummer: 11

ISSN: 1439-4227

DOI Link: https://doi.org/10.1002/cbic.201300268

Verlag: Wiley

Abstract: 
Unlike their terrestrial counterparts, marine myxobacteria are hardly investigated for their secondary metabolites. This study describes three new compounds (1-3), named salimyxins and enhygrolides, obtained from the obligate marine myxobacterium Enhygromyxa salina. These are the first natural products obtained from Enhygromyxa species. Their structures were elucidated by spectroscopic analysis, including NMR and CD spectroscopy. Enhygrolides are closely related to the nostoclides, which were initially isolated from a cyanobacterium of the genus Nostoc. The salimyxins, representing structurally most unusual degraded sterols, are close to identical to demethylincisterol from the sponge Homaxinella sp. Salimyxin B and enhygrolide A inhibit the growth of the Gram-positive bacterium Arthrobacter cristallopoietes (MIC salimyxin B, 8 gmL(-1); enhygrolide A, 4 gmL(-1)).

Harvard-Zitierstil: Felder, S., Kehraus, S., Neu, E., Bierbaum, G., Schäberle, T. and König, G. (2013) Salimyxins and Enhygrolides: Antibiotic, Sponge-Related Metabolites from the Obligate Marine Myxobacterium Enhygromyxa salina, ChemBioChem, 14(11), pp. 1363-1371. https://doi.org/10.1002/cbic.201300268

APA-Zitierstil: Felder, S., Kehraus, S., Neu, E., Bierbaum, G., Schäberle, T., & König, G. (2013). Salimyxins and Enhygrolides: Antibiotic, Sponge-Related Metabolites from the Obligate Marine Myxobacterium Enhygromyxa salina. ChemBioChem. 14(11), 1363-1371. https://doi.org/10.1002/cbic.201300268