Journalartikel

Jahr der Veröffentlichung: 2006

Seiten: 244-250

Zeitschrift: Journal of Chromatography A

Bandnummer: 1128

Heftnummer: 1-2

DOI Link: https://doi.org/10.1016/j.chroma.2006.06.070

Verlag: Elsevier

Abstract: 

HPTLC/MS by a plunger-based extraction device was shown to be an appropriate technique for quantitative planar chromatography, even in trace analysis. Reproducible extraction from silica gel phases in the lower-pg range distinguishes this technique from other approaches. Repeatability of the MS signal showed a mean RSD of 12.5% for the example of Harman, a heterocyclic aromatic amine. Analytical response within a plate and over various plates/days showed determination coefficients of 0.9915 and 0.9488, respectively. Limit of detection (LOD) by a single quadrupole was better than 40 pg and limit of quantitation (LOQ) by a tandem mass spectrometer better than 20 pg. LOQ/LOD obtained were of similar magnitude as reported for HPLC/MS methods, however, this order of sensitivity was shown for the first time in the field of HPTLC/electrospray ionization Ms. (c) 2006 Elsevier B.V. All rights reserved.

Harvard-Zitierstil: Jautz, U. and Morlock, G. (2006) Efficacy of planar chromatography coupled to (tandem) mass spectrometry for employment in trace analysis, Journal of Chromatography A, 1128(1-2), pp. 244-250. https://doi.org/10.1016/j.chroma.2006.06.070

APA-Zitierstil: Jautz, U., & Morlock, G. (2006). Efficacy of planar chromatography coupled to (tandem) mass spectrometry for employment in trace analysis. Journal of Chromatography A. 1128(1-2), 244-250. https://doi.org/10.1016/j.chroma.2006.06.070