Journalartikel

Jahr der Veröffentlichung: 2019

Seiten: 104294-

Zeitschrift: Fitoterapia: Bioactives from plants and fungi

Bandnummer: 138

DOI Link: https://doi.org/10.1016/j.fitote.2019.104294

Verlag: Elsevier

Abstract: 

Two new eremophilane-type sesquiterpenes, carperemophilanes A and B (1–2), three new maleimide-bearing compounds, carpesiumaleimides A–C (3–5), along with a known sesquiterpene, carabrol (6), were isolated from the ethanol extract of Carpesium abrotanoides L. Their structures were elucidated by analysis of their NMR and MS data as well as by comparison with the literature. The absolute configuration of carperemophilane A (1) was determined by single-crystal X-ray diffraction analysis. All isolated compounds (1–6) were evaluated in vitro for cytotoxicity against two human cancer cell lines MDA-MB-231 and HGC-27 using the MTT method. Compounds 1, 2 and 6 showed cytotoxic activities with IC₅₀ values ranging from 7.45 to 37.35 μM.

Harvard-Zitierstil: Wang, L., Jin, G., Tian, L., Ebrahim, W., Höfert, S., Janiak, C., et al. (2019) New eremophilane-type sesquiterpenes and maleimide-bearing compounds from Carpesium abrotanoides L., Fitoterapia: Bioactives from plants and fungi, 138, p. 104294. https://doi.org/10.1016/j.fitote.2019.104294

APA-Zitierstil: Wang, L., Jin, G., Tian, L., Ebrahim, W., Höfert, S., Janiak, C., Chen, J., Guo, Z., Schäberle, T., Liu, Z., Proksch, P., & Zou, K. (2019). New eremophilane-type sesquiterpenes and maleimide-bearing compounds from Carpesium abrotanoides L.. Fitoterapia: Bioactives from plants and fungi. 138, 104294. https://doi.org/10.1016/j.fitote.2019.104294