Journal article

Publication year: 2019

Pages: 400-404

Journal: Cytokine

Volume number: 113

ISSN: 1043-4666

DOI Link: https://doi.org/10.1016/j.cyto.2018.10.012

Publisher: Elsevier

Abstract: 
Aim Metreleptin treatment in lipodystrophy patients improves eating behavior with increased satiety and reduced hunger. However, no data are available whether effects are maintained beyond 52 weeks of treatment.Methods: A prospective study with measurements at baseline and at > 150 weeks of metreleptin treatment was performed. Five female lipodystrophy patients with indication for metreleptin were included. Behavioral aspects of hunger- and satiety regulation were assessed by validated eating behavior questionnaires and visual analog scales assessing hunger and satiety feelings before and after a standardized meal.Results: Hunger rated on visual analog scales at 120 min after the meal significantly decreased from 46 +/- 10 mm at baseline to 17 +/- 6 mm at long-term assessment. Furthermore, satiety at 5 and 120 min after the meal significantly increased from baseline to long-term assessment (5 min: 70 +/- 7 mm to 87 +/- 3 mm; 120 min: 43 +/- 10 mm to 79 +/- 8 mm). On the Three Factor Eating Questionnaire, the mean value of factor 3 (hunger) significantly decreased from 9.2 +/- 0.2 at baseline to 2.6 +/- 1.5 at long-term assessment. In the Inventory of Eating Behavior and Weight Problems Questionnaire, mean values for scale 2 (strength and triggering of desire to eat) and scale 7 (cognitive restraint of eating) significantly decreased from baseline (31.6 +/- 4.8 and 11.4 +/- 2.2, respectively) to long-term assessment (14.0 +/- 2.1 and 10.0 +/- 1.9).Conclusion: First evidence is presented that long-term metreleptin treatment of > 150 weeks has sustained effects on eating behavior with increased satiety, as well as reduced hunger and hunger-related measures.

Harvard Citation style: Püschel, J., Miehle, K., Müller, K., Villringer, A., Stumvoll, M., Fasshauer, M., et al. (2019) Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment, Cytokine, 113, pp. 400-404. https://doi.org/10.1016/j.cyto.2018.10.012

APA Citation style: Püschel, J., Miehle, K., Müller, K., Villringer, A., Stumvoll, M., Fasshauer, M., & Schlögl, H. (2019). Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment. Cytokine. 113, 400-404. https://doi.org/10.1016/j.cyto.2018.10.012