Journal article

Publication year: 2018

Pages: 165-168

Journal: Cytokine

Volume number: 106

ISSN: 1043-4666

DOI Link: https://doi.org/10.1016/j.cyto.2017.10.028

Publisher: Elsevier

Abstract: 
Objective: Fetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis. Regulation of fetuin B in patients with lipodystrophy (LD) - a disease group which is characterized by subcutaneous adipose tissue loss, hypertriglyceridemia, hepatic steatosis, insulin resistance , and dysregulation of several adipokines - has not been elucidated so far.Material and methods: Serum fetuin B levels were determined in 37 patients with LD, as well as in a control cohort consisting of 37 non-LD participants matched for age, gender, and body mass index. Furthermore, fetuin B was correlated with parameters of lipid metabolism, glucose control, renal function, and inflammation.Results: Median fetuin B serum levels were not significantly different between patients with LD (2980.7 mu g/l; interquartile range: 841.7 mu g/l) and non-LD controls (2647.3 mu g/l; interquartile range: 923.6 mu g/l; p = .105). Fetuin B was associated with age, body mass index, markers of renal function, and C reactive protein (CRP) in univariate correlation analyses. The associations with age and creatinine remained significant in multiple linear regression analysis.Conclusions: Fetuin B serum concentrations are not significantly different between patients with LD and non-LD controls. Fetuin B does not seem to be a major pathogenetic factor in LD.

Harvard Citation style: Miehle, K., Ebert, T., Kralisch, S., Hoffmann, A., Kratzsch, J., Schlögl, H., et al. (2018) Serum concentrations of fetuin B in lipodystrophic patients, Cytokine, 106, pp. 165-168. https://doi.org/10.1016/j.cyto.2017.10.028

APA Citation style: Miehle, K., Ebert, T., Kralisch, S., Hoffmann, A., Kratzsch, J., Schlögl, H., Stumvoll, M., & Fasshauer, M. (2018). Serum concentrations of fetuin B in lipodystrophic patients. Cytokine. 106, 165-168. https://doi.org/10.1016/j.cyto.2017.10.028