Journal article

Publication year: 2018

Pages: 150-154

Journal: Diabetes & Metabolism

Volume number: 44

Issue number: 2

ISSN: 1262-3636

DOI Link: https://doi.org/10.1016/j.diabet.2017.06.001

Publisher: Elsevier

Abstract: 
Aims. - Neuregulin 4 has recently been recognized as a novel adipokine secreted by brown adipose tissue (BAT), with beneficial effects on murine insulin resistance and hepatic steatosis. Yet, thus far, neither regulation of neuregulin 4 in gestational diabetes mellitus (GDM) nor its longitudinal changes in the peripartum period have been elucidated.Methods. - Circulating neuregulin 4 levels were measured by ELISA in 74 women with GDM and 74 healthy, gestational-age-matched controls. Also, neuregulin 4 was quantified during pregnancy and compared with postpartum levels in a follow-up study of 25 women with previous GDM and 25 healthy control women.Results. - Women with GDM had lower median serum levels of the novel BAT-secreted adipokine neuregulin 4 (3.0 a) compared with healthy (non-GDM) pregnant controls (3.5 mu g/L; P = 0.020), and the area under the glucose curve (AUC(Giuco)) was an independent and negative predictor of circulating neuregulin 4 (P = 0.033). Also, median postpartum serum concentrations of neuregulin 4 (3.2 mu g/L) were not significantly different from prepartum levels (2.8 mu g/L; P = 0.328). In addition, neuregulin 4 was positively and independently associated with irisin (P= 0.009), but not other BAT-secreted adipokines.Conclusion/interpretation. - Women with GDM have significantly lower circulating neuregulin 4 levels compared with healthy pregnant controls, and the AUCGiucose is negatively and independently associated with neuregulin 4 during pregnancy. Neuregulin 4 is positively correlated with irisin during pregnancy, as well as in a longitudinal fashion. Future studies are now needed to better elucidate the precise pathomechanisms of the regulation of BAT-secreted adipokines during pregnancy. (C) 2017 Elsevier Masson SAS. All rights reserved.

Harvard Citation style: Kralisch, S., Hoffmann, A., Kratzsch, J., Blüher, M., Stumvoll, M., Fasshauer, M., et al. (2018) The brown-fat-secreted adipokine neuregulin 4 is decreased in gestational diabetes mellitus, Diabetes & Metabolism, 44(2), pp. 150-154. https://doi.org/10.1016/j.diabet.2017.06.001

APA Citation style: Kralisch, S., Hoffmann, A., Kratzsch, J., Blüher, M., Stumvoll, M., Fasshauer, M., & Ebert, T. (2018). The brown-fat-secreted adipokine neuregulin 4 is decreased in gestational diabetes mellitus. Diabetes & Metabolism. 44(2), 150-154. https://doi.org/10.1016/j.diabet.2017.06.001