Journalartikel

Jahr der Veröffentlichung: 2015

Seiten: 461-470

Zeitschrift: Trends in Pharmacological Sciences

Bandnummer: 36

Heftnummer: 7

ISSN: 0165-6147

DOI Link: https://doi.org/10.1016/j.tips.2015.04.014

Verlag: Cell Press

Abstract: 
Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are peptides that signal the functional status of adipose tissue to targets in the brain, liver, pancreas, immune system, vasculature, muscle, and other tissues. Secretion of adipokines, including leptin, adiponectin, fibroblast growth factor 21 (FGF21), retinol-binding protein 4 (RBP4), dipeptidyl peptidase 4 (DPP-4), bone morphogenetic protein (BMP)-4, BMP-7, vaspin, apelin, and progranulin, is altered in adipose tissue dysfunction and may contribute to a spectrum of obesity-associated diseases. Adipokines are promising candidates both for novel pharmacological treatment strategies and as diagnostic tools, provided that we can develop a better understanding of the function and molecular targets of the more recently discovered adipokines.

Harvard-Zitierstil: Fasshauer, M. and Blüher, M. (2015) Adipokines in health and disease, Trends in Pharmacological Sciences, 36(7), pp. 461-470. https://doi.org/10.1016/j.tips.2015.04.014

APA-Zitierstil: Fasshauer, M., & Blüher, M. (2015). Adipokines in health and disease. Trends in Pharmacological Sciences. 36(7), 461-470. https://doi.org/10.1016/j.tips.2015.04.014