Journal article

Publication year: 2015

Pages: 338-343

Journal: Cytokine

Volume number: 75

Issue number: 2

ISSN: 1043-4666

DOI Link: https://doi.org/10.1016/j.cyto.2015.07.021

Publisher: Elsevier

Abstract: 
Background: Adipokines contribute to the development of preeclampsia (PE), a severe pregnancy complication which increases the future risk for cardiovascular and metabolic disease in both mother and newborn. Pre-adipocyte factor-1 (Pref-1) was recently introduced as a novel antiangiogenic and antiadipogenic adipokine.Material and methods: Pref-1 was quantified in patients with PE (n = 51) and healthy pregnant controls (n = 51) during pregnancy, as well as 6 months after delivery (study population 1). Furthermore, Pref-1 was investigated in the immediate peripartal period and the placenta in 40 healthy pregnant women undergoing elective cesarean section (study population 2).Results: In study population 1, median Pref-1 serum concentrations during pregnancy were significantly lower in women with PE (0.5 mu g/l) as compared to healthy pregnant controls (0.7 mu g/l) (p <0.001). Furthermore, Pref-1 serum concentrations were independently predicted by PE, leptin levels, and gestational age in this population. In both study populations, Pref-1 serum levels significantly decreased after delivery as compared to prepartal levels. Moreover, significant expression of Pref-1 was detected in placental tissue.Conclusion: Maternal Pref-1 serum concentrations are significantly decreased in PE. The pathophysiological significance of this regulation needs to be studied in more detail in future experiments. (C) 2015 Elsevier Ltd. All rights reserved.

Harvard Citation style: Schrey, S., Wurst, U., Ebert, T., Kralisch, S., Drewlo, S., Stepan, H., et al. (2015) The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta, Cytokine, 75(2), pp. 338-343. https://doi.org/10.1016/j.cyto.2015.07.021

APA Citation style: Schrey, S., Wurst, U., Ebert, T., Kralisch, S., Drewlo, S., Stepan, H., Lössner, U., Platz, M., Kratzsch, J., Stumvoll, M., & Fasshauer, M. (2015). The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta. Cytokine. 75(2), 338-343. https://doi.org/10.1016/j.cyto.2015.07.021