Journal article
Authors list: Stepan, H; Kley, K; Hindricks, J; Kralisch, S; Jank, A; Schaarschmidt, W; Schrey, S; Ebert, T; Lössner, U; Kratzsch, J; Blüher, M; Stumvoll, M; Richter, J; Fasshauer, M
Publication year: 2013
Pages: 322-326
Journal: Cytokine
Volume number: 62
Issue number: 2
ISSN: 1043-4666
DOI Link: https://doi.org/10.1016/j.cyto.2013.02.019
Publisher: Elsevier
Abstract:
Background: Preeclampsia (PE) is a serious cardiovascular complication in pregnancy, which is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Fibroblast growth factor (FGF)-21 was recently introduced as a novel adipokine improving glucose metabolism in vitro and in vivo.Material and methods: We investigated serum FGF-21 levels in patients with PE (n = 51) as compared to healthy, age-matched controls (n = 51) during and 6 months after pregnancy. Furthermore, association of FGF-21 with markers of renal function, glucose and lipid metabolism, as well as inflammation, was elucidated in all individuals.Results: Median maternal FGF-21 serum concentrations adjusted for body mass index and gestational age at blood sampling were significantly, almost 3-fold increased in PE patients (309.6 ng/l) as compared to healthy, age-matched pregnant women (105.2 ng/l) (p < 0.001). Furthermore, FGF-21 concentrations were independently and positively correlated with triglycerides whereas an independent and negative association was observed with glomerular filtration rate and low density lipoprotein (LDL) cholesterol in pregnant women. Moreover, FGF-21 serum levels significantly decreased in former PE patients 6 months after pregnancy approaching levels found in control patients.Conclusions: Maternal FGF-21 serum concentrations are significantly increased in PE during pregnancy. Furthermore, triglycerides, glomerular filtration rate, and LDL cholesterol are independent predictors of circulating FGF-21 in pregnant women. (C) 2013 Elsevier Ltd. All rights reserved.
Citation Styles
Harvard Citation style: Stepan, H., Kley, K., Hindricks, J., Kralisch, S., Jank, A., Schaarschmidt, W., et al. (2013) Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia, Cytokine, 62(2), pp. 322-326. https://doi.org/10.1016/j.cyto.2013.02.019
APA Citation style: Stepan, H., Kley, K., Hindricks, J., Kralisch, S., Jank, A., Schaarschmidt, W., Schrey, S., Ebert, T., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., Richter, J., & Fasshauer, M. (2013). Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia. Cytokine. 62(2), 322-326. https://doi.org/10.1016/j.cyto.2013.02.019