Journal article

Publication year: 2012

Pages: 1230-1234

Journal: Pancreas

Volume number: 41

Issue number: 8

ISSN: 0885-3177

DOI Link: https://doi.org/10.1097/MPA.0b013e31824e2d93

Publisher: Lippincott, Williams & Wilkins

Abstract: 
Objective: Chronic pancreatitis (CP) is associated with an increased risk for diabetes mellitus and vascular disease. Adipocyte fatty acidbinding protein (AFABP) is a novel adipokine that is independently associated with the metabolic syndrome and cardiovascular disease. In the current study, we investigated serum AFABP levels in CP patients compared with sex- and body mass indexYmatched controls.Methods: Adipocyte fatty acidYbinding protein was determined with enzyme- linked immunosorbent assay in control subjects (n = 60) and diabetic as well as nondiabetic CP (n = 60) patients and correlated to clinical and biochemical measures of glucose and lipid metabolism, as well as renal function in both groups.Results: Median serum AFABP levels were significantly lower in CP patients compared with controls (12.5 vs 20.9 Kg/L, P = 0.003). Furthermore, body mass index, sex, and CP independently predicted circulating AFABP. In contrast, no significant difference in circulating AFABP could be demonstrated between diabetic and nondiabetic CP patients.Conclusions: Circulating AFABP is paradoxically lower in CP patients and does not depend on pancreatic diabetes. Our data do not support a role of circulating AFABP in metabolic and vascular risk in CP patients.

Harvard Citation style: Selig, L., Reiche, M., Ebert, T., Krehl, D., Kralisch, S., Lössner, U., et al. (2012) Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Decreased in Chronic Pancreatitis, Pancreas, 41(8), pp. 1230-1234. https://doi.org/10.1097/MPA.0b013e31824e2d93

APA Citation style: Selig, L., Reiche, M., Ebert, T., Krehl, D., Kralisch, S., Lössner, U., Stach, B., Blüher, M., Stumvoll, M., Bödeker, H., Keim, V., Mössner, J., & Fasshauer, M. (2012). Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Decreased in Chronic Pancreatitis. Pancreas. 41(8), 1230-1234. https://doi.org/10.1097/MPA.0b013e31824e2d93