Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: 562-565

Zeitschrift: Journal of Endocrinological Investigation

Bandnummer: 35

Heftnummer: 6

ISSN: 1720-8386

DOI Link: https://doi.org/10.3275/7877

Verlag: Springer

Abstract: 
Background: Preeclampsia (PE) is associated with facets of the metabolic syndrome and an increased future metabolic and cardiovascular risk for mother and newborn. Recently, zinc-alpha 2-glycoprotein (ZAG) has been proposed as a new adipokine involved in the pathogenesis of obesity. Aim: In the current study, we investigated ZAG serum levels in PE patients as compared to healthy gestational age-matched controls. Subjects and methods: We quantified serum concentrations of ZAG in patients with PE (no.=37) as compared to healthy gestational age-matched controls (no.=37) by enzyme-linked immunosorbent assay. Furthermore, association of this adipokine with renal function, glucose and lipid metabolism, as well as inflammation was studied. Results: Median serum ZAG levels were 1.4-fold higher in PE patients (58.8 mg/l) as compared to controls (41.9 mg/l) (p<0.01). Furthermore, circulating ZAG was positively correlated to systolic and diastolic blood pressure, creatinine, triglycerides, and leptin in univariate analyses. In multiple regression analysis, creatinine remained independently associated with ZAG. Conclusions: We demonstrate that maternal ZAG serum concentrations are significantly increased in PE. Furthermore, renal function is an independent predictor of circulating ZAG. (J. Endocrinol. Invest. 35: 562-565, 2012) (C) 2012, Editrice Kurtis

Harvard-Zitierstil: Stepan, H., Philipp, A., Roth, I., Kralisch, S., Jank, A., Schaarschmidt, W., et al. (2012) Serum levels of the adipokine zinc-alpha 2-glycoprotein are increased in preeclampsia, Journal of Endocrinological Investigation, 35(6), pp. 562-565. https://doi.org/10.3275/7877

APA-Zitierstil: Stepan, H., Philipp, A., Roth, I., Kralisch, S., Jank, A., Schaarschmidt, W., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2012). Serum levels of the adipokine zinc-alpha 2-glycoprotein are increased in preeclampsia. Journal of Endocrinological Investigation. 35(6), 562-565. https://doi.org/10.3275/7877